Health Blog & Videos
By Andrew Mai, MD
Turning 50 doesn't just mark a new decade — it marks a shift in how the body handles food. Muscle mass declines by roughly 1–2% a year after 50 if lef...
By Andrew Mai, MD
步入50岁，改变的不仅是年龄数字, 更是身体处理食物的方式。若不加以干预, 50岁后肌肉量每年会下降约1-2%, 骨密度随之降低, 营养吸收效率也逐渐减弱。而对于这一年龄段中已经患有一种或多种慢性病——高血压、2型糖尿病、心血管疾病、骨关节炎或骨质疏松症——的众多成年人来说, 营养已不再是一种生活方...
By Andrew Mai, MD
**From passive prevention to measurable rejuvenation — how targeted exosome therapy and senolytic clearance work together to reverse markers of cellul...
By Andrew Mai, MD
** 从被动预防到可衡量的年轻化- 靶向外泌体疗法与衰老细胞清除，如何协同逆转细胞衰老的标志物。 此刻，你的体内正潜伏着"僵尸细胞"，它们悄然拖慢器官运转，加速你的生物学年龄。但如果我们能派出微观"抢修队"将其清除呢？以下是当靶向外泌体信号与细胞衰变正面交锋时会发生的事——以及新兴生物标志物数据正...
By Andrew Mai, MD
Cellular biology has a new object of fascination in food science: exosome-like nanoparticles (ELNs) — tiny lipid-bound vesicles, roughly 30–150 nanome...
By Andrew Mai, MD
细胞生物学领域出现了一个令食品科学界着迷的新研究对象: 外泌体样纳米颗粒(exosome-like nanoparticles, ELNs)。这是一种微小的脂质囊泡, 直径大约在30到150纳米之间, 由植物细胞释放, 其方式与人类和动物细胞释放外泌体的方式颇为相似。这些颗粒内部含有微小RNA(mi...
By Andrew Mai, MD
Skin aging has long been treated as a one-way street — a slow accumulation of damage that creams and lasers can only soften, never reverse. But a grow...
By Andrew Mai, MD
长期以来，皮肤衰老一直被视为一条单行道——是精华液与激光只能减缓、却无法逆转的损伤累积过程。但越来越多的再生医学研究正在挑战这一假设。这一转变的核心在于细胞衰老：真皮成纤维细胞停止分裂、停止合成胶原蛋白，转而向周围组织释放炎症信号，主动降解组织结构的过程。 外用外泌体疗法正逐渐成为直接应对这一过程的...
By Andrew Mai, MD
Aging is often described as a slow accumulation of damage, but at the cellular level it looks more like a communication breakdown. As we get older, th...
By Andrew Mai, MD
衰老常被描述为损伤的缓慢累积, 但从细胞层面来看, 它更像是一场通讯系统的崩溃。随着年龄增长, 那些原本协调组织运作的"信息"——告诉干细胞该去哪里、何时分裂、如何平息炎症——开始变得混乱, 甚至彻底中断。过去十年间, 再生医学领域最令人振奋的进展之一, 就是发现我们可以直接干预这套信号系统,而实现...
By Dr. Andrew Mai, MD - amhealth.ca
A century ago, living past 70 was the exception. Today it's the expectation across most of the developed world. Now a more audacious number is enterin...
By Dr. Andrew Mai, MD - amhealth.ca
一个世纪前,能活过70岁是少数人的幸运; 如今,在大多数发达地区,这已成为普遍的预期。而现在, 一个更大胆的数字正进入公众视野：150岁。这并非某种保证, 更不是长生不老的承诺——而是一个严肃的长期目标:如果我们把已知的生物学知识与人工智能处理健康数据的能力结合起来, 健康、有功能的人类寿命究竟能延...
By Andrew Mai, MD
大多数服用 NAD+ 前体 - 烟酰胺核糖(NR)、烟酰胺单核苷酸(NMN)或普通烟酰胺的人,都是在早上和其他补充剂一起服用。这是个合理的习惯,但未必是最符合生物学规律的做法。NAD+ 的可利用性、去乙酰化酶(sirtuin)活性以及线粒体修复能力都会随 24 小时周期波动，越来越多的昼夜节律生物学...
By Andrew Mai, MD
Most people who take NAD+ precursors — nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), or plain nicotinamide — take them in the morning...
By Andrew Mai, MD
If you wake up with your heart already racing, your mind already sprinting through the day's to-do list before your feet hit the floor, you might assu...
By Andrew Mai, MD
What if every night you stay up late, waste products quietly accumulate inside your brain? During deep, slow-wave sleep, cerebrospinal fluid (CSF) was...
By Andrew Mai, MD
如果告诉你,每当你熬夜晚睡,大脑内部就会悄悄积累废物,你会作何感想?在深度慢波睡眠期间,脑脊液(CSF)会流经脑组织,帮助带走代谢废物——其中就包括β-淀粉样蛋白,这是与阿尔茨海默病关联最密切的蛋白片段。如果长期缺乏这一睡眠阶段,研究表明,大脑所承受的废物负荷会比正常情况更重。 这就是"淋巴系统"...
By Andrew Mai, MD
患者面临的问题 尿失禁仍是前列腺手术后最持久影响生活质量的问题之一。即使采用现代保留神经的手术技术,相当一部分男性在根治性前列腺切除术后仍会出现压力性尿失禁(SUI),而仅靠保守治疗的效果也参差不齐。人工尿道括约肌、尿道悬吊术等手术方式确实有效,但创伤较大,伴随各自的并发症风险,也并非适合所有患者。...
By Andrew Mai, MD
The Problem Patients Face Urinary incontinence remains one of the most persistent quality-of-life burdens after prostate surgery. Even with modern ner...
By Andrew Mai, MD
引言 血管衰老——大动脉的进行性僵硬化以及微血管系统内皮功能的衰退——如今被认为是年龄相关疾病中最早、也是最具决定性影响的驱动因素之一。早在患者出现明显的动脉粥样硬化、高血压或认知功能下降之前,血管壁内已经发生了可测量的变化:一氧化氮生物利用度降低、低度慢性炎症("炎性衰老")、氧化应激,以及衰老...
By Andrew Mai, MD
Introduction Vascular aging — the progressive stiffening of large arteries and the decline of endothelial function in the microvasculature — is now r...
By Andrew Mai, MD
引言 良性前列腺增生（BPH）与前列腺癌是影响老龄男性最常见的两种前列腺疾病，尽管二者在病理生理上截然不同，却常常发生在同一器官、同一患者身上，甚至同时出现。BPH是前列腺移行区腺体与间质组织的良性、非恶性增生，可导致尿路梗阻并影响生活质量。前列腺癌则是一种恶性病变，主要起源于外周区，其临床谱系从可...
By Andrew Mai, MD
Introduction Benign prostatic hyperplasia (BPH) and prostate cancer are the two most common prostatic conditions affecting aging men, yet they are pa...
By Andrew Mai, MD
Most conversations about aging joints start at the knee: cartilage wear, mechanical load, maybe a supplement stack of glucosamine and chondroitin. But...
By Andrew Mai, MD
关于关节衰老的讨论,大多从膝盖本身说起:软骨磨损、机械负荷,或许再加上一套氨基葡萄糖和软骨素补剂。但越来越多的骨科与微生物组研究开始将目光投向更上游的部位——肠道黏膜。这一新兴概念被称为"肠-关节轴"(gut-joint axis),它将关节僵硬重新定义为:与其说是局部的磨损问题,不如说是一种下游后...
By Andrew Mai, MD
干细胞疗法是现代医学中讨论最多的前沿领域之一,同时也是最容易被误解的领域之一。对于面临严重疾病或危及生命疾病的患者而言,利用人体自身的修复细胞来治疗疾病这一理念显然极具吸引力。本文将概述再生干细胞疗法的实际内涵、目前已被证实具有临床价值的应用领域、仍处于研究阶段的领域,以及患者在考虑接受该疗法前应了...
By Andrew Mai, MD
Stop treating your joint pain like a squeaky door hinge that just needs grease. For decades, that's exactly how we've approached osteoarthritis — top ...
By Andrew Mai, MD
不要再把关节疼痛当成一扇需要上油的吱呀作响的门铰链了。几十年来，我们对待骨关节炎的方式正是如此——注射粘弹补充剂、等效果消退、再重复一次。但一个新兴的研究方向正在提出一个更根本的问题：如果目标不是给关节"补油"，而是重新启动本应维持关节润滑的生物机制呢？ 这一机制的核心是大多数患者从未听说过的两种...
By Andrew Mai, MD
Osteoarthritis (OA) is the most common form of arthritis worldwide and one of the leading causes of disability in older adults. As the global populati...
By Andrew Mai, MD
骨关节炎(Osteoarthritis, OA)是全球最常见的关节炎类型,也是老年人致残的主要原因之一。随着全球人口老龄化,骨关节炎的患病率持续上升,无论是对个人生活质量还是对医疗系统而言,预防与有效管理都变得愈发重要。本文将回顾衰老为何会增加骨关节炎风险、 如何预防或延缓其发生,以及当前的治疗方案...
By Andrew Mai, MD
Aging is not an inevitable decline; it is a metabolic process that can be strategically managed. While headline-grabbing anti-aging protocols often em...
By Andrew Mai, MD
Most executives are unintentionally sabotaging their brain chemistry — not through negligence, but through outdated, one-size-fits-all health advice. ...
By Andrew Mai, MD
许多高管都在无意中损害着自己的脑化学机制——这并非疏忽所致,而是源于过时的、千篇一律的健康建议。现在是2026年8月,能够在细胞层面测量生物年龄的工具已不再局限于研究实验室。如果你还没有关注自己的代谢和微生物组究竟在做什么,那么你的"优化"其实是盲目的。 以下是更坦诚的说法：科学确实取得了进展。但...
By Andrew Mai, MD
长期以来，失智症被视为衰老不可避免的结果，一旦发生只能设法应对,而非提前预防。这种认知已经过时。近年来，学界对可改变风险因素的理解发生了重大转变，阿尔茨海默病史上首批具有疾病修饰作用的药物也相继问世，预防与治疗两方面都取得了实质性进展。 预防：近一半的失智症风险可以改变 失智症预防研究领域近期最...
By Andrew Mai, MD
Dementia has long been framed as an inevitable consequence of aging — something to be managed once it arrives, not something to be headed off. That fr...
By Andrew Mai, MD
Exosome therapy has moved from a niche research topic to one of the most searched terms in regenerative and sports medicine. Athletes and weekend warr...
By Andrew Mai, MD
Introduction Across traumatic brain injury (TBI), stroke, post-acute COVID-19 cognitive impairment, and early neurodegenerative disease, a common thre...
By Andrew Mai, MD
Stem cell therapy is one of the most discussed frontiers in modern medicine — and also one of the most misunderstood. For patients facing serious or l...
By Dr. Andrew Mai
Why consistent monitoring and early detection are crucial for long-term wellness....
By Dr. Andrew Mai
Learn how BMI, heart rate, and other vital signs contribute to your overall health picture....
By Dr. Andrew Mai
How digital health tools can help you better manage ongoing health conditions....
By Dr. Andrew Mai
<p>The Mediterranean diet is a way of eating based on the traditional foods of countries surrounding the Mediterranean Sea. It's rich in fruits, veget...
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